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1094-61-7
Whatsapp/Skype:008619565680882
Threema id :AAVXFAZX
mail:rachel@whhoyan.com
| Product Name: | β-Nicotinamide Mononucleotide |
| Synonyms: | 3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE;1-[3,4-dihydroxy-5-[(hydroxy-oxido-phosphoryl)oxymethyl]oxolan-2-yl]pyridine-5-carboxamide;β-Nicotinamide ribose monophosphate, β-NMN, Nicotinamide ribotide, NMN, Nicotinamide-1-ium-1-β-D-ribofuranoside 5μ-phosphate;1-Deoxy-1-(3-carbamoylpyridinio)-5-O-oxylatophosphonyl-β-D-ribofuranose;Nicotinamide ribonucleoside 5'-phosphate;β-D-NMN;3-(AMinocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)pyridiniuM Inner Salt |
| CAS: | 1094-61-7 |
| MF: | C11H15N2O8P |
| MW: | 334.22 |
| EINECS: | 214-136-5 |
| Product Categories: | nicotinamide mononucleotide;Pharmaceuticals;Amines;Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals;Nicotine Derivatives;Nucleotides;API;BETA-NICOTINAMI;API;NMN;1094-61-7;nutrition supplement |
| Mol File: | 1094-61-7.mol |
 | |
Use:
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.
At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
Whatsapp/Skype:008619565680882
Threema id :AAVXFAZX
mail:rachel@whhoyan.com
| Product Name: | β-Nicotinamide Mononucleotide |
| Synonyms: | 3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE;1-[3,4-dihydroxy-5-[(hydroxy-oxido-phosphoryl)oxymethyl]oxolan-2-yl]pyridine-5-carboxamide;β-Nicotinamide ribose monophosphate, β-NMN, Nicotinamide ribotide, NMN, Nicotinamide-1-ium-1-β-D-ribofuranoside 5μ-phosphate;1-Deoxy-1-(3-carbamoylpyridinio)-5-O-oxylatophosphonyl-β-D-ribofuranose;Nicotinamide ribonucleoside 5'-phosphate;β-D-NMN;3-(AMinocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)pyridiniuM Inner Salt |
| CAS: | 1094-61-7 |
| MF: | C11H15N2O8P |
| MW: | 334.22 |
| EINECS: | 214-136-5 |
| Product Categories: | nicotinamide mononucleotide;Pharmaceuticals;Amines;Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals;Nicotine Derivatives;Nucleotides;API;BETA-NICOTINAMI;API;NMN;1094-61-7;nutrition supplement |
| Mol File: | 1094-61-7.mol |
| |
Use:
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.
At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
